Page 3 - CIBERESP-2015-eng

Scientific
Director’s Presentation
The pages in this report give details of the main actions carried out and results achieved during the 2015 period at CIBERESP and its research groups. Some of these are set forth below:
In the strategic sub-programme entitled Multi- Case-Control of Cancer, with 7500 cases and 3500 controls, a genetic analysis has been completed with the Exome array (Illumina). It takes part in the following international consortiums: PRACTICAL/ prostate; BCAC/breast; STOP/ stomach; Interlymph and ICGC/CLL; Exposomics/ colorectal; breast can- cer shift work case-control studies. Some of the sig- nificant results are the influence of night-shift work on breast and prostate cancer, the association be- tween diabetes and its treatment with breast cancer and the effect of perinatal and childhood factors in breast cancer.
A cooperative project is being carried out on the “Effectiveness of the whooping cough vaccination in women in the third trimester of pregnancy to pre- vent whooping cough” and it has taken part in the meetings with the Health Ministry and the regional ministries to modify the vaccine calendar and in- clude a dose in the third trimester of pregnancy.
The Platform of Longitudinal Studies on Immigrant Families has been consolidated, starting the cohorts, and with participation in the Work Package on “Ac- cess of the migrant population to HIV diagnosis and care”; EURO-EDAT Project: The European HIV Early Diagnosis and Access to Treatment (DG SANCO).
In the sub-programme on the “effect of the crisis and social-economic inequalities on mortality” an analy- sis has been made of the evolution of inequalities in suicide and of inequalities in the main causes of mortality in several Spanish administrative regions. This has repercussions in the healthcare system: increase of the consumption of psychotropic drugs and of suicide rates with the crisis.
The INMA sub-programme has had numerous re- sults and many are in cooperation with other Eu- ropean cohorts and included in projects such as CHICOS and the EGG and EAGLE genetic studies. The main discoveries of the INMA Project refer to the role of environmental agents (DDE, BPA, phtha- lates, etc.) in obesity and asthma and the epigenetic markers of xenoestrogens in childhood.
In the “Carga de enfermedad” (Burden of Disease) sub-programme the cohort of Social Security mem- bers from 2004/2013 has been reconstructed, con- sisting of 1022779 persons, with 0.49% permanent incapacity, and 0.24% mortality. In the Essencial pro- ject, to avoid low-value clinical practices, 45 recom- mendations have been published along with several scientific societies (http://essencialsalut.gencat. cat/ca/): 22 are implemented in a pilot study with 75 primary care teams. In BiblioPRO 2897 new users have been registered and this already has 1354 in- struments.
In the study of the healthcare clinical process (MAPAC) results have been achieved changing healthcare practice, as well as continuing with the Diana-salud digital platform (www.dianasalud.com). A systematic review on the effect of epilepsy and its treatment on reproductive results was published in the Lancet (2015; 386:1845-52).
Four short stays abroad were financed in the Train- ing Programme. The Excellence Encounter was held at the Public Health Summer School of Minorca. 10 awards for the best papers presented at the SEE Sci- entific Meeting were financed.
Miguel Delgado Rodríguez Scientific Director
CIBERESP I Annual report 2015 I 3