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pregnant women from the 12th week of pregnancy and their children up to 7-8 years.
MCC SPAIN. Poblational multicase-control study that was initiated in 2008 with funding from the Transversal Action in Cancer, to investigate the influence of environmental factors and their interaction with genetic factors in common or with peculiar epidemiologic characteristics tumors in our country (colorectal, breast, stomach, prostate and chronic lymphatic leukemia).
Most relevant scientific articles
• López-Espinosa M.-J., Murcia M., Íniguez C., Vizcaíno E., Costa O., Fernández-Somoano A. et al. Organochlorine compounds and ultrasound measurements of fetal growth in the INMA cohort (Spain). Environmental Health Perspectives. 2016;124(1):157-163.
• Llop S, Ballester F, Murcia M, Forns J, Tardón A, Andiarena A et al. Prenatal exposure to mercury and neuropsychological development in young children: the role of fish consumption.International journal of epidemiology. 2016.
• Bigert C., Gustavsson P., Straif K., Taeger D., Pesch B., Kendzia B. et al. Lung cancer among firefighters: Smoking-adjusted risk estimates in a pooled analysis of case-control studies. Journal of Occupational and Environmental Medicine. 2016;58(11):1137-1143.
• Scholz A., Giménez-Monzo D., Navarrete-Munoz E.M., García-De-la-Hera M., Fernández-Somoano A., Tardón A. et al. Dietary intake of trans fatty acids in children aged 4–5 in Spain: The INMA cohort study. Nutrients. 2016;8(10).
• Íniguez C., Esplugues A., Sunyer J., Basterrechea M., Fernández-Somoano A., Costa O. et al. Prenatal exposure to NO2 and ultrasound measures of fetal growth in the Spanish INMA cohort. Environmental Health Perspectives. 2016;124(2):235-242.
Highlights
In lung cancer, study CAPUA, we have conducted in collaboration with the SYNERGY project of IARC, an array of occupation-exposition (SYN-JEM) for the development of occupational exposure variables to assess relations occupation-exposition in lung cancer and estimate the interactions between occupational carcinogens. Study CAPUA in ILCCO is part of the international basis “The database of genotype and Phenotypes (dbGaP)”, including genome-wide association, sequencing, molecular diagnosis, genotype and treatment. The objective is to increase the power of detection of genetic factors influencing all histological types of lung cancer, to be able to analyze, cancers that make their debut very young, of certain histological characteristics, groups of never-smokers or women. The breadth of these studies GWAS sample will allow studying the interactions of gene and environment on lung cancer, with the ultimate goal of identifying individuals and groups at high risk can lead to screening and early detection in lung cancer. Bladder cancer in collaboration with NCI and the CNIO, have continued the exploration and analysis
of genetic susceptibility, through application of pathways analysis factors candidates and multi-single nucleotide polymorphism (multi-SNP), by Bayesian analysis to detect the main effects of variants of genes of bladder cancer and inflammation. In the INMA cohort we have completed follow-up at age 7 with a
rate of 93,55%, the highest of the INMA project tracking. We have signed an agreement with the Ministry of health of Asturias to participate in the Plan of the air quality in Gijón. We have participated in the drafting of the Plan of quality of the air of Gijón and Avilés. We have participated in the drafting of the Guide Clinic: recommendations about nutrition with iodine in the preconception stage, pregnancy and lactation. Technical report.
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