Page 88 - CIBERESP-2015-eng

Research groups
Group 20
Programme: Epidemiology and Environmental and Occupational Risk Prevention
Lead Researcher: Marcos Dauder, Ricardo
Group Members
STAFF MEMBERS: Pastor Benito, Susana.
ASSOCIATED MEMBERS: Alarcón Sánchez, Lourdes | Baida Gil, Aída | Creus Capdevilla, Amadeu | Guillamet Cros, Emma | Hernández Bonilla, Alba | López Castel, Arturo | Soriano Tarraga, Carolina | Velázquez Henar, Antonia | Xamena López, Noel.
Main lines of research
Genotoxic/carcinogenic mechanisms of arsenic. This research field involves both in vitro and biomonitoring studies with exposed populations. The most interest- ing recent results can be summarized as:
In the human populations studied (Chile and Mexico), the exposed people (never mind if they are occupation- ally or environmentally exposed) present high levels of genetic damage. / We have found a new polymorphism of the AS3MT gene (Met287Thr) acting as an impor- tant modulator of the genetic risk. Individuals carrying such variant accumulate the metabolite MMA(III) that is the arsenic specie showing the highest genotoxic potentiality. / We have generated a wide set of in vitro tools to evaluate the carcinogenic potential of arsenic. / We have demonstrated for first time that oxidative damage plays an important role in both the genotoxici- ty and carcinogenicity of arsenic.
Risk factors in patients with thyroid pathologies. LThe most important goals reached in this research line can
be summarized as follows:
We have found a region in chromosome 1p12 show- ing a strong association with thyroid cancer. In this region there is a new gene (WDR3) responsible of the observed association. / We have found associations between different genes involved in the repair of DNA (OGG1, XRCC1, XRCC2 and XRCC3) and the metabo- lism of thyroid (TG) and the thyroid cancer. / In a wide study of all the genome (GWA), carried out with sam- ples from four European populations we have found a strong association with the rs6759952 polymorphism of the DIRC3 gene. / Finally, in a collaborative study with Italian groups we have shown for first time that the thyroperoxidase gene (TPO) is involved in the risk of suffering thyroid cancer.
Risk factors in patients with kidney thyroid patholo- gies. The most important recent goals of this research line are as follows:
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