Page 90 - CIBERESP2016-ENG

lEaD rESEarCHEr
Marcos Dauder, Ricardo
Universidad Autónoma de Barcelona
Edifici C (Facultat Biociències) Campus UAB. 2a Planta
08193 Cerdanyola | Barcelona (+34) 93 581 20 52 [email protected]
group website
GROUP MEMBERS
Staff members: Pastor, Susana
Associated members: Alarcón Sánchez, Lourdes | Baida Gil, Aida | Creus Capdevilla, Amadeu | Guillamet Cros, Emma | Hernández Bonilla, Alba | López Castel, Arturo | Velázquez Henar, Antonia | Xamena López, Noel
Main lines of research
• Genotoxic/carcinogenic mechanisms of arsenic.
This research field involves both in vitro and biomonitoring studies with exposed populations. The most interesting recent results can be summarized as:
In the human populations studied (Chile and Mexico), the exposed people (never mind if they are occupationally or environmentally exposed) present high levels of genetic damage. / We have found a
new polymorphism of the AS3MT gene (Met287Thr) acting as an important modulator of the genetic risk. Individuals carrying such variant accumulate the metabolite MMA(III) that is the arsenic specie showing the highest genotoxic potentiality. / We have generated a wide set of in vitro tools to evaluate the carcinogenic potential of arsenic. / We have demonstrated for first time that oxidative damage plays an important role in both the genotoxicity and carcinogenicity of arsenic.
• Risk factors in patients with thyroid pathologies.
The most important goals reached in this research line can be summarized as follows:
We have found a region in chromosome 1p12 showing a strong association with thyroid cancer. In this region, there is a new gene (WDR3) responsible of the observed association / We have found associations between different genes involved in the repair of DNA (OGG1, XRCC1, XRCC2 and XRCC3) and the metabolism of thyroid (TG) and the thyroid cancer. / In a wide study of all the genome (GWA), carried out with samples from four European populations we have found a strong association with the rs6759952 polymorphism of the DIRC3 gene. / Finally, in a collaborative study with Italian groups we have shown for first time that the thyroperoxidase gene (TPO) is involved in the risk of suffering thyroid cancer.
• Risk factors in patients with kidney thyroid pathologies. The most important recent goals of this research line are as follows:
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PROGRAMME
Epidemiology and Prevention of Environmental and Occupational Diseases