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• Identification of new therapeutic targets
We use of bioinformatics tools for the identification of genes involved in cancer. This is a complex task since it requires in vivo and in vitro validation of hypotheses generated by bioinformatics models using genomic and proteomic data.
Most relevant scientific articles
• Binefa G., García M., Mila N., Fernández E., Rodríguez-Moranta F., Gonzalo N. et al. Colorectal Cancer Screening Programme in Spain: Results of Key Performance Indicators after Five Rounds (2000- 2012). Scientific Reports. 2016;6.
• Sanz-Pamplona R., Gil-Hoyos R., López-Doriga A., Alonso M.H., Ausso S., Mollevi D.G. et al. Mutanome and expression of immune response genes in microsatellite stable colon cancer. Oncotarget. 2016;7(14):17711-17725.
• Mur P., Elena S.-C., Ausso S., Aiza G., Rafael V.-M., Pineda M. et al. Scarce evidence of the causal role of germline mutations in UNC5C in hereditary colorectal cancer and polyposis. Scientific Reports. 2016;6.
• Belhadj S., Mur P., Navarro M., González S., Moreno V., Capella G. et al. Delineating the Phenotypic Spectrum of the NTHL1-Associated Polyposis. Clinical Gastroenterology and Hepatology. 2016.
• Cantarino N., Musulen E., Valero V., Peinado M.A., Perucho M., Moreno V. et al. Downregulation of the deiminase PADI2 is an early event in colorectal carcinogenesis and indicates poor prognosis. Molecular Cancer Research. 2016;14(9):841-848.
Highlights
This year we have been awarded two new research projects, a FIS entitled “Characterization and classification by molecular subtype of interval tumors in the population screening of colorectal cancer”, in which one of the principal investigators is Rebeca Sanz. The grant is € 147,000.
Also, a grant from the Spanish Association Against Cancer (AECC), entitled “Cost-effectiveness and budgetary impact of three preventive strategies in lung cancer.”
Two members of the group have read the doctoral thesis: David Cordero, entitled “Molecular analysis of colorectal cancer using an integrative computational approach” and Adriana López-Dóriga, entitled “Analysis of new generation sequencing data for molecular diagnosis of hereditary cancer and for the investigation of the genetic basis of sporadic colorectal cancer.”
ESP
Research groups 97